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SKF-96365 HCl

Catalog No.: 16062905
Cas No.: 130495-35-1
Purity : 98% by HPLC 
16062905 - SKF-96365 HCl | CAS 130495-35-1

Catalog number : 16062905

CAS number : 130495-35-1

Molecular Formula : C22H27ClN2O3 

Molecular Weight : 402.919 

Iupac Chemical Name : 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride 

Smile : Cl.COC1=CC=C(C=C1)C(CN1C=NC=C1)OCCCC1=CC=C(C=C1)OC

InChiKey : FWLPKVQUECFKSW-UHFFFAOYSA-N

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SynonymsSKF-96365; SKF 96365 
Molecular FormulaC22H27ClN2O3 
Molecular Weight402.919 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCl.COC1=CC=C(C=C1)C(CN1C=NC=C1)OCCCC1=CC=C(C=C1)OC
InChiKeyFWLPKVQUECFKSW-UHFFFAOYSA-N
InChiInChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
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SKF-96365 is a selective TRPC channel blocker. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKII/AKT-mediated pathway. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes. SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). SKF-96365 attenuates toxin-induced neuronal injury through opposite regulatory effects on Homer1a and Homer1b/c in cultured rat mesencephalic cells. 

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