SJ-172550
SJ-172550, also known as MDMX Inhibitor II, is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.
For research use only. We do not sell to patients.
Chemical Information
| Name | SJ-172550 |
|---|---|
| Iupac Chemical Name | methyl (Z)-2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)phenoxy)acetate |
| Synonyms | SJ-172550; SJ 172550; SJ172550. MDMX Inhibitor II. |
| Molecular Formula | C22H21ClN2O5 |
| Molecular Weight | 428.87 |
| Smile | ClC1=CC(/C=C2C(N(C3=CC=CC=C3)N=C\2C)=O)=CC(OCC)=C1OCC(OC)=O |
| InChiKey | RKKFQJXGAQWHBZ-YVLHZVERSA-N |
| InChi | InChI=1S/C22H21ClN2O5/c1-4-29-19-12-15(11-18(23)21(19)30-13-20(26)28-3)10-17-14(2)24-25(22(17)27)16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3/b17-10- |
| CAS Number | 431979-47-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012;7(6):e37518. doi: 10.1371/journal.pone.0037518. Epub 2012 Jun 4. PubMed PMID: 22675482; PubMed Central PMCID: PMC3366986.
2: Leão M, Gomes S, Bessa C, Soares J, Raimundo L, Monti P, Fronza G, Pereira C, Saraiva L. Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules. Exp Cell Res. 2015 Jan 1;330(1):164-77. doi: 10.1016/j.yexcr.2014.09.028. Epub 2014 Sep 28. PubMed PMID: 25265062.
3: Lemos A, Leão M, Soares J, Palmeira A, Pinto M, Saraiva L, Sousa ME. Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction. Med Res Rev. 2016 Sep;36(5):789-844. doi: 10.1002/med.21393. Epub 2016 Jun 15. Review. PubMed PMID: 27302609.
4: Noushini S, Alipour E, Emami S, Safavi M, Ardestani SK, Gohari AR, Shafiee A, Foroumadi A. Synthesis and cytotoxic properties of novel (E)-3-benzylidene-7-methoxychroman-4-one derivatives. Daru. 2013 Apr 12;21(1):31. doi: 10.1186/2008-2231-21-31. PubMed PMID: 23587260; PubMed Central PMCID: PMC3668990.
5: Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. PubMed PMID: 20080970; PubMed Central PMCID: PMC2856285.
6: Leão M, Gomes S, Soares J, Bessa C, Maciel C, Ciribilli Y, Pereira C, Inga A, Saraiva L. Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity. FEBS J. 2013 Dec;280(24):6498-507. doi: 10.1111/febs.12552. Epub 2013 Oct 23. PubMed PMID: 24119020.
7: Soares J, Raimundo L, Pereira NA, dos Santos DJ, Pérez M, Queiroz G, Leão M, Santos MM, Saraiva L. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins. Pharmacol Res. 2015 May-Jun;95-96:42-52. doi: 10.1016/j.phrs.2015.03.006. Epub 2015 Mar 23. PubMed PMID: 25814188.
Chemical Structure
