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SIS3

Catalog No.: 16122721
Cas No.: 521984-48-5
Purity : 98% 
16122721 - SIS3 | CAS 521984-48-5

Catalog number : 16122721

CAS number : 521984-48-5

Molecular Formula : C28H27N3O3.HCl 

Molecular Weight : 489.99 

Iupac Chemical Name : SIS3 

Smile : Cn1c(c(c2c1nccc2)/C=C/C(=O)N3CCc4cc(c(cc4C3)OC)OC)c5ccccc5.Cl

InChiKey : CDKIEBFIMCSCBB-CALJPSDSSA-N

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SynonymsN/A 
Molecular FormulaC28H27N3O3.HCl 
Molecular Weight489.99 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCn1c(c(c2c1nccc2)/C=C/C(=O)N3CCc4cc(c(cc4C3)OC)OC)c5ccccc5.Cl
InChiKeyCDKIEBFIMCSCBB-CALJPSDSSA-N
InChiInChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
MDLMFCD09265258
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SIS3, a novel specific inhibitor of Smad3, inhibits TGF- and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. SIS3 also inhibits the myofibroblast differentiation of fibroblasts by TGF-1. SIS3 completely diminishes the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts, thus abolishes the ECM overexpression in the TGF-1-treated normal dermal fibroblasts and scleroderma fibroblasts in vitro 

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