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SIS3

Catalog No: 16122721
CAS Number: 521984-48-5
Purity: 98% 

SIS3, a novel specific inhibitor of Smad3, inhibits TGF- and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. SIS3 also inhibits the myofibroblast differentiation of fibroblasts by TGF-1. SIS3 completely diminishes the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts, thus abolishes the ECM overexpression in the TGF-1-treated normal dermal fibroblasts and scleroderma fibroblasts in vitro 

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Chemical Information

NameSIS3
Iupac Chemical NameSIS3 
SynonymsN/A 
Molecular FormulaC28H27N3O3.HCl 
Molecular Weight489.99 
SmileCn1c(c(c2c1nccc2)/C=C/C(=O)N3CCc4cc(c(cc4C3)OC)OC)c5ccccc5.Cl
InChiKeyCDKIEBFIMCSCBB-CALJPSDSSA-N
InChiInChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
CAS Number521984-48-5
MDLMFCD09265258
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122721 - SIS3 | CAS 521984-48-5

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