SILA-123
Catalog No: 26A014
CAS Number: 2911585-37-8
Purity: ≧98.0%
SILA-123 is a type II FLT3 inhibitor that has shown highly potent inhibitory effects against FLT3-WT (IC50 = 2.1 nM) and FLT3-ITD (IC50 = 1.0 nM), tumor cells with the FLT3-ITD mutant such as MOLM-13 (IC50 = 0.98 nM) and MV4-11 (IC50 = 0.19 nM), as well as BaF3 cells associated with the FLT3-ITD mutant and point mutations like BaF3-FLT3-ITD-G697R (IC50 = 3.0 nM).
For research use only. We do not sell to patients.
Chemical Information
| Name | SILA-123 |
|---|---|
| Iupac Chemical Name | 1-[4-(3-amino-6-methyl-[1,2]oxazolo[5,4-b]pyridin-4-yl)phenyl]-3-(4-tert-butylphenyl)urea |
| Synonyms | SILA-123 ; SILA123 ; SILA 123 |
| Molecular Formula | C24H25N5O |
| Molecular Weight | 415.20 |
| Smile | O=C(NC1=CC=C(C(C)(C)C)C=C1)NC2=CC=C(C3=C4C(ON=C4N)=NC(C)=C3)C=C2 |
| InChiKey | ZUXJIOLLSSLCOH-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H25N5O2/c1-14-13-19(20-21(25)29-31-22(20)26-14)15-5-9-17(10-6-15)27-23(30)28-18-11-7-16(8-12-18)24(2,3)4/h5-13H,1-4H3,(H2,25,29)(H2,27,28,30) |
| CAS Number | 2911585-37-8 |
| Related CAS | 2911585-37-8 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
