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SHP394

Catalog No.: 193122
Cas No.: 2055757-40-7
Purity : >98%

SHP394 is a potent and orally active SHP2 inhibitor (IC50 = 23 nM) with high lipophilic efficiency, improved potency, and enhanced pharmacokinetic properties.

For research use only. We do not sell to patients.

Chemical Information

NameSHP394
Iupac Chemical Name6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-methyl-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrimidin-4(3H)-one
SynonymsSHP394; SHP-394; SHP 394;
Molecular FormulaC20H25F3N6O2S
Molecular Weight470.5152
SmileO=C1N(C)C(N(CC2)CCC32[C@H](N)[C@H](C)OC3)=NC(N)=C1SC4=CC=CN=C4C(F)(F)F
InChiKeyQZHZIDHAIVAHMD-SMDDNHRTSA-N
InChiInChI=1S/C20H25F3N6O2S/c1-11-14(24)19(10-31-11)5-8-29(9-6-19)18-27-16(25)13(17(30)28(18)2)32-12-4-3-7-26-15(12)20(21,22)23/h3-4,7,11,14H,5-6,8-10,24-25H2,1-2H3/t11-,14+/m0/s1
CAS Number2055757-40-7
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid to white solid
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

193122 - SHP394 | CAS 2055757-40-7

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