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SGC707

Catalog No.: 17011702
Cas No.: 1687736-54-4
Purity : 98% 

SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 is a potent PRMT3 inhibitor (IC50 =312 nM, KD =532 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). The mechanism of action studies and crystal structure of the PRMT3-SGC707 complex confirm the allosteric inhibition mode. Importantly, SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease. 

For research use only. We do not sell to patients.

Chemical Information

NameSGC707
Iupac Chemical NameN-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea 
SynonymsSGC-707; SGC 707 
Molecular FormulaC16H18N4O2 
Molecular Weight298.346 
SmileC1=NC=CC2=CC(=CC=C12)NC(=O)NCC(N1CCCC1)=O
InChiKeyDMIDPTCQPIJYFE-UHFFFAOYSA-N
InChiInChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
CAS Number1687736-54-4
Related CAS

Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17011702 - SGC707 | CAS 1687736-54-4

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