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SGC707

Catalog No.: 17011702
Cas No.: 1687736-54-4
Purity : 98% 
17011702 - SGC707 | CAS 1687736-54-4

Catalog number : 17011702

CAS number : 1687736-54-4

Molecular Formula : C16H18N4O2 

Molecular Weight : 298.346 

Iupac Chemical Name : N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea 

Smile : C1=NC=CC2=CC(=CC=C12)NC(=O)NCC(N1CCCC1)=O

InChiKey : DMIDPTCQPIJYFE-UHFFFAOYSA-N

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SynonymsSGC-707; SGC 707 
Molecular FormulaC16H18N4O2 
Molecular Weight298.346 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC1=NC=CC2=CC(=CC=C12)NC(=O)NCC(N1CCCC1)=O
InChiKeyDMIDPTCQPIJYFE-UHFFFAOYSA-N
InChiInChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
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SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 is a potent PRMT3 inhibitor (IC50 =312 nM, KD =532 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). The mechanism of action studies and crystal structure of the PRMT3-SGC707 complex confirm the allosteric inhibition mode. Importantly, SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease. 

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