SDU-071
SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 suppresses BRD4 interaction with the p53 tumor suppressor and its biological activity in MDA-MB-231 triple-negative breast cancer (TNBC) cells in vitro and in vivo. SDU-071 suppresses cell proliferation, migration, and invasion by downregulating the expression of BRD4-targeted genes, such as c-Myc and Mucin 5AC, and inducing cell cycle arrest and apoptosis, as demonstrated in cultured MDA-MB-231 TNBC cells. Its antitumor activity is illustrated in an orthotopic mouse xenograft mammary tumor model. SDU-071 is a viable option for potentially treating TNBC as a new BRD4-p53 inhibitor.
For research use only. We do not sell to patients.
Chemical Information
| Name | SDU-071 |
|---|---|
| Iupac Chemical Name | N-(4-methoxyphenyl)-2-(((4-methoxyphenyl)amino)methyl)benzo[h]quinolin-4-amine |
| Synonyms | SDU-071; SDU 071; SDU071 |
| Molecular Formula | C28H25N3O2 |
| Molecular Weight | 435.52 |
| Smile | COC(C=C1)=CC=C1NC2=CC(CNC3=CC=C(OC)C=C3)=NC4=C5C(C=CC=C5)=CC=C42 |
| InChiKey | ZWWQETFJXKSVFP-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H25N3O2/c1-32-23-12-8-20(9-13-23)29-18-22-17-27(30-21-10-14-24(33-2)15-11-21)26-16-7-19-5-3-4-6-25(19)28(26)31-22/h3-17,29H,18H2,1-2H3,(H,30,31) |
| CAS Number | 3036109-10-8 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells
Shumei Wang, Kang Lei, Hsien-Tsung Lai, Tingting Liu, Lupei Du, Shwu-Yuan Wu, Xiaohan Ye, Cheng-Ming Chiang, and Minyong Li
ACS Pharmacology & Translational Science 2024 7 (4), 1178-1190
DOI: 10.1021/acsptsci.4c00057
Chemical Structure
