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SC66

Catalog No.: 17011701
Cas No.: 871361-88-5
Purity : 98% 
17011701 - SC66 | CAS 871361-88-5

Catalog number : 17011701

CAS number : 871361-88-5

Molecular Formula : C18H16N2O 

Molecular Weight : 276.33 

Iupac Chemical Name : (2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexanone 

Smile : N1=CC=C(C=C1)\C=C/1\C(/C(/CCC1)=C/C1=CC=NC=C1)=O

InChiKey : CYVVJSKZRBZHAV-UNZYHPAISA-N

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SynonymsSC66; SC 66 
Molecular FormulaC18H16N2O 
Molecular Weight276.33 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileN1=CC=C(C=C1)\C=C/1\C(/C(/CCC1)=C/C1=CC=NC=C1)=O
InChiKeyCYVVJSKZRBZHAV-UNZYHPAISA-N
InChiInChI=1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
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SC66 is a novel and potent AKT inhibitor, which reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reduction in total and phospho-AKT levels. SC66 significantly potentiated the effects of both conventional chemotherapeutic and targeted agents, doxorubicin and everolimus, respectively. In vivo, SC66 inhibited tumor growth of Hep3B cells in xenograft models, with a similar mechanism observed in the in vitro model. SC66 had antitumor effects on HCC cells. 

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