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SAR131675

Catalog No.: 17011605
Cas No.: 1092539-44-0
Purity : 98% 
17011605 - SAR131675 | CAS 1092539-44-0

Catalog number : 17011605

CAS number : 1092539-44-0

Molecular Formula : C18H22N4O4 

Molecular Weight : 358.398 

Iupac Chemical Name : 2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide 

Smile : NC=1N(C2=NC(=CC=C2C(C1C(=O)NC)=O)C#CC(COC)(C)O)CC

InChiKey : PFMPOBVAYMTUOX-UHFFFAOYSA-N

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SynonymsSAR 131675; SAR-131675 
Molecular FormulaC18H22N4O4 
Molecular Weight358.398 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileNC=1N(C2=NC(=CC=C2C(C1C(=O)NC)=O)C#CC(COC)(C)O)CC
InChiKeyPFMPOBVAYMTUOX-UHFFFAOYSA-N
InChiInChI=1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)
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SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion. 

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