Avutometinib ( Synonyms: Ro 5126766; CH5126766 )
Catalog No: 25152
CAS Number: 946128-88-7
Purity: ≧98.0%
Avutometinib ( Synonyms: Ro 5126766; CH5126766 )is a potent and selective dual RAF/MEK inhibitor. Avutometinib can strongly inhibit MEK1/2 kinase activity and induce the formation of dominant negative RAF/MEK complexes, thereby blocking the compensatory activation of MEK by RAF.
For research use only. We do not sell to patients.
Chemical Information
| Name | Avutometinib ( Synonyms: Ro 5126766; CH5126766 ) |
|---|---|
| Iupac Chemical Name | 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one |
| Synonyms | Ro5126766 ; Ro 5126766 ; CH-5126766 ; CH5126766 ; CH 5126766 ; CKI-27 ;R-7304 ;RG-7304 ; VS-6766 |
| Molecular Formula | C21H18FN5O5S |
| Molecular Weight | 471.462 |
| Smile | CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F |
| InChiKey | LMMJFBMMJUMSJS-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27) |
| CAS Number | 946128-88-7 |
| Related CAS | 946128-88-7 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature |
| HS Code | 2934200090 |
Coming soon.
| Targets | RAF/MEK抑制剂 |
|---|---|
| Mechanism | Avutometinib是一种RAF/MEK抑制剂，它能够诱导MEK与ARAF、BRAF和CRAF形成非活性复合物，可能通过最大程度地抑制RAS信号通路产生更全面和持久的抗肿瘤反应。与其他MEK抑制剂不同，avutometinib既能阻止MEK激酶活性，也能阻止RAF磷酸化MEK。这种独特的机制使avutometinib能够阻止MEK信号，而不触发补偿性的MEK激活。 |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
