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Ro 5126766

Catalog No.: 010812
Cas No.: 946128-88-7
Purity : 98% 
010812 - Ro 5126766 | CAS 946128-88-7

Catalog number : 010812

CAS number : 946128-88-7

Molecular Formula : C21H18FN5O5S 

Molecular Weight : 471.462 

Chemical Name : Ro 5126766

Smile : CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F

InChiKey : LMMJFBMMJUMSJS-UHFFFAOYSA-N

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SynonymsRo5126766; Ro 5126766; CH-5126766; CH5126766; CH 5126766 
Molecular FormulaC21H18FN5O5S 
Molecular Weight471.462 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
InChiKeyLMMJFBMMJUMSJS-UHFFFAOYSA-N
InChiInChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27)
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Ro 5126766 is a potent and selective dual RAF/MEK inhibitor. For SK-MEL-28, SK-MEL-2, MIAPaCa-2, and SW480 cell lines, the IC50 is determined by WST-8 assay is 65, 28, 40, and 46 nM, respectively. 

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