Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.
For research use only. We do not sell to patients.
| Name | Rigosertib sodium |
|---|---|
| Iupac Chemical Name | Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate |
| Synonyms | ON01910; ON 01910; ON-01910; Rigosertib sodium |
| Molecular Formula | C21H24NNaO8S |
| Molecular Weight | 473.47 |
| Smile | COc1ccc(cc1NCC(=O)[O-])CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC.[Na+] |
| InChiKey | VLQLUZFVFXYXQE-USRGLUTNSA-M |
| InChi | InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+; |
| CAS Number | 1225497-78-8 |
| MDL | MFCD11655911 |
| Related CAS |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | light-yellow solid to off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | 50mg/ml in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |