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Remibrutinib ( LOU064 )

Catalog No.: 2073103
Cas No.: 1787294-07-8
Purity : 98% Min.

Remibrutinib ( LOU064 ) is a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. Remibrutinib ( LOU064 ) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for a best-in-class covalent BTK inhibitor for the treatment of autoimmune diseases. It demonstrates potent in vivo target occupancy with an EC90 of 1.6 mg/kg and dose-dependent efficacy in rat collagen-induced arthritis. Remibrutinib ( LOU064 ) is currently being tested in phase 2 clinical studies for chronic spontaneous urticaria and Sjoegren’s syndrome.

For research use only. We do not sell to patients.

Chemical Information

NameRemibrutinib ( LOU064 )
Iupac Chemical NameN-(3-(6-amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide
SynonymsRemibrutinib ; LOU064 ; LOU 064 ; LOU-064
Molecular FormulaC27H27F2N5O3
Molecular Weight507.53
SmileO=C(NC1=CC(F)=CC(C2=NC=NC(N)=C2OCCN(C)C(C=C)=O)=C1C)C3=CC=C(C4CC4)C=C3F
InChiKeyCUABMPOJOBCXJI-UHFFFAOYSA-N
InChiInChI=1S/C27H27F2N5O3/c1-4-23(35)34(3)9-10-37-25-24(31-14-32-26(25)30)20-12-18(28)13-22(15(20)2)33-27(36)19-8-7-17(11-21(19)29)16-5-6-16/h4,7-8,11-14,16H,1,5-6,9-10H2,2-3H3,(H,33,36)(H2,30,31,32)
CAS Number1787294-07-8
Related CAS1787294-07-8

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid to white solid
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

2073103 - Remibrutinib ( LOU064 ) | CAS 1787294-07-8

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