Relacorilant
Relacorilant is discontinued.
For research use only. We do not sell to patients.
Chemical Information
| Name | Relacorilant |
|---|---|
| Iupac Chemical Name | [(4aR)-1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazole-4-sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin- 2-yl]methanone |
| Synonyms | Relacorilant, CORT125134; CORT-125134; CORT 125134. |
| Molecular Formula | C27H22F4N6O3S |
| Molecular Weight | 586.56 |
| Smile | O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C1CCN(S(=O)(C5=CN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6 |
| InChiKey | WANIDIGFXJFFEL-SANMLTNESA-N |
| InChi | InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1 |
| CAS Number | 1496510-51-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J,
Phillips T, Swift D, Eaton E. Identification of the Clinical Candidate
(R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexah
ydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methano
ne (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem.
2017 Apr 17. doi: 10.1021/acs.jmedchem.7b00162. [Epub ahead of print] PubMed
PMID: 28368581.
2: Bali U, Phillips T, Hunt H, Unitt J. FKBP5 mRNA Expression Is a Biomarker for
GR Antagonism. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. Epub 2016 Jul
26. PubMed PMID: 27459525.
3: Stringer-Reasor EM, Baker GM, Skor MN, Kocherginsky M, Lengyel E, Fleming GF,
Conzen SD. Glucocorticoid receptor activation inhibits chemotherapy-induced cell
death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015
Sep;138(3):656-62. doi: 10.1016/j.ygyno.2015.06.033. Epub 2015 Jun 24. PubMed
PMID: 26115975; PubMed Central PMCID: PMC4556542.
Chemical Structure
