Rabusertib(LY2603618)
Catalog No: 52807
CAS Number: 911222-45-2
Purity: 98%
LY2603618(IC-83) is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC50=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials.
For research use only. We do not sell to patients.
Chemical Information
| Name | Rabusertib(LY2603618) |
|---|---|
| Iupac Chemical Name | (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea |
| Synonyms | LY2603618; LY 2603618; LY-2603618; Rabusertib |
| Molecular Formula | C18H22BrN5O3 |
| Molecular Weight | 436.3 |
| Smile | Cc1cc(c(cc1Br)NC(=O)Nc2cnc(cn2)C)OC[C@@H]3CNCCO3 |
| InChiKey | SYYBDNPGDKKJDU-ZDUSSCGKSA-N |
| InChi | InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1 |
| CAS Number | 911222-45-2 |
| MDL | MFCD18633253 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Purity | 98% |
|---|---|
| Solubility | DMSO ��20mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| Handling | |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. Compositions of Chk1 kinase inhibitor for cancer treatment By Colvin, Anita A.; Koppenol, Sandy; Wisdom, Wendy A. From PCT Int. Appl. (2008), WO 2008067027 A2 20080605.
Chemical Structure
