RU320521
RU320521, also known as RU521; RU.521 is a potent and selective inhibitor of cGAS, inhibiting cGAS-mediated signaling, being active in murine bone marrow-derived macrophage.
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Chemical Information
| Name | RU320521 |
|---|---|
| Iupac Chemical Name | 3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one InChi Key: VIQXILLOJLATEF-UHFFFAOYSA-N |
| Synonyms | RU320521; RU-320521; RU 320521; RU521; RU-521; RU 521; RU.521; |
| Molecular Formula | C19H12Cl2N4O3 |
| Molecular Weight | 415.23 |
| Smile | O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5 |
| InChiKey | VIQXILLOJLATEF-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,26H,1H3,(H,22,23) |
| CAS Number | 2262452-06-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | 固体粉末 |
|---|---|
| Purity | 98% Min. |
| Storage | 干燥、黑暗，短期（日至周）在0-4摄氏度，长期（月至年）在-20摄氏度。 |
| Solubility | 可溶于DMSO |
| Handling | |
| Shipping Condition | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周。 |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Items 1-5 of 5 (Display the 5 citations in PubMed)
1: Inoue K, Ishizawa M, Kubota T. Monoclonal anti-dsDNA antibody 2C10 escorts DNA to intracellular DNA sensors in normal mononuclear cells and stimulates secretion of multiple cytokines implicated in lupus pathogenesis. Clin Exp Immunol. 2020 Feb;199(2):150-162. doi: 10.1111/cei.13382. Epub 2019 Oct 29. PMID: 31604370; PMCID: PMC6954677.
2: Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11946-11955. doi: 10.1073/pnas.1905013116. Epub 2019 May 29. PMID: 31142647; PMCID: PMC6575157.
3: Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026. PMID: 30007416; PMCID: PMC6084792.
4: Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M. Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Nov 23;8(1):1827. doi: 10.1038/s41467-017-01770-3. Erratum for: Nat Commun. 2017 Sep 29;8(1):750. PMID: 29170402; PMCID: PMC5700994.
5: Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750. doi: 10.1038/s41467-017-00833-9. Erratum in: Nat Commun. 2017 Nov 23;8(1):1827. PMID: 28963528; PMCID: PMC5622107.
Chemical Structure
