RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.
For research use only. We do not sell to patients.
| Name | RU-SKI 43 |
|---|---|
| Iupac Chemical Name | RU-SKI 43 |
| Synonyms | RU-SKI43; Hhat Inhibitor |
| Molecular Formula | C22H30N2O2S |
| Molecular Weight | 386.55 |
| InChiKey | |
| InChi | |
| CAS Number | 1043797-53-0 |
| Related CAS |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |