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RPI-1

Catalog No.: 17030301
Cas No.: 269730-03-2
Purity : 98% 
17030301 - RPI-1 | CAS 269730-03-2

Catalog number : 17030301

CAS number : 269730-03-2

Molecular Formula : C17H15NO4 

Molecular Weight : 297.31 

Iupac Chemical Name : 1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one 

Smile : OC1=CC=C(C=C1)C=C1C(NC2=CC(=C(C=C12)OC)OC)=O

InChiKey : JGSMCYNBVCGIHC-UHFFFAOYSA-N

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SynonymsRPI-1; RPI1; RPI 1 
Molecular FormulaC17H15NO4 
Molecular Weight297.31 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileOC1=CC=C(C=C1)C=C1C(NC2=CC(=C(C=C12)OC)OC)=O
InChiKeyJGSMCYNBVCGIHC-UHFFFAOYSA-N
InChiInChI=1S/C17H15NO4/c1-21-15-8-12-13(7-10-3-5-11(19)6-4-10)17(20)18-14(12)9-16(15)22-2/h3-9,19H,1-2H3,(H,18,20)
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RPI-1 is an ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. Following treatment suspension, tumor inhibition was maintained (51%, P<0.05, 100 days) and cures were achieved in 2/11 mice. In vivo effects of RPI-1 were reflected in activation of BAD, cleavage of caspases, apoptotic DNA fragmentation and inhibition of VEGF production observed in in vitro RPI-1-treated TT cells. 

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