RPI-1
Catalog No: 17030301
CAS Number: 269730-03-2
Purity: 98%
RPI-1 is an ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. Following treatment suspension, tumor inhibition was maintained (51%, P<0.05, 100 days) and cures were achieved in 2/11 mice. In vivo effects of RPI-1 were reflected in activation of BAD, cleavage of caspases, apoptotic DNA fragmentation and inhibition of VEGF production observed in in vitro RPI-1-treated TT cells.
For research use only. We do not sell to patients.
Chemical Information
| Name | RPI-1 |
|---|---|
| Iupac Chemical Name | 1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one |
| Synonyms | RPI-1; RPI1; RPI 1 |
| Molecular Formula | C17H15NO4 |
| Molecular Weight | 297.31 |
| Smile | OC1=CC=C(C=C1)C=C1C(NC2=CC(=C(C=C12)OC)OC)=O |
| InChiKey | JGSMCYNBVCGIHC-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H15NO4/c1-21-15-8-12-13(7-10-3-5-11(19)6-4-10)17(20)18-14(12)9-16(15)22-2/h3-9,19H,1-2H3,(H,18,20) |
| CAS Number | 269730-03-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
