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RO9021

Catalog No: 17109007
CAS Number: 1446790-62-0
Purity: 98% 

RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.


RO9021 suppresses BCR signaling in human peripheral blood mononuclear cells (PBMC) and whole blood, FcR signaling in human monocytes, and FcR signaling in human mast cells and blocks osteoclastogenesis from mouse bone marrow macrophages in vitro. Toll-like Receptor(TLR) 9 signaling in human Bcells was inhibited by RO9021, resulting in decreased levels of plasmablasts, immunoglobulin (Ig)M and IgG upon B-cell differentiation. RO9021 also potently inhibited type I interferon production by human plasmacytoid dendritic cells (pDC) upon TLR9 activation. This effect is specific to TLR9 as RO9021 did not inhibit TLR4- or JAK-STAT-mediated signaling. RO9021 does not appreciably inhibit the JAK-STAT pathway.


 

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Chemical Information

NameRO9021
Iupac Chemical NameRO9021 
SynonymsN/A 
Molecular FormulaC18H25N7O 
Molecular Weight355.44 
InChiKey
InChi
CAS Number1446790-62-0
Related CAS

Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17109007 - RO9021 | CAS 1446790-62-0

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