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RO8994

Catalog No: 1673101
CAS Number: 1309684-94-3
Purity: 98% 

RO8994 is a potent and selective spiroindolinone MDM2 inhibitor for cancer therapy. 

For research use only. We do not sell to patients.

Chemical Information

NameRO8994
Iupac Chemical Name(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide 
SynonymsRO8994; RO-8994; RO 8994 
Molecular FormulaC31H31Cl2FN4O4 
Molecular Weight613.5 
SmileC(N)(=O)C1=CC(=C(C=C1)NC(=O)[C@H]1[C@H]([C@@]2([C@@H](N1)CC(C)(C)C)C(NC1=CC(=CC=C12)Cl)=O)C1=C(C(=CC=C1)Cl)F)OC
InChiKeyMURAVORBGFDSMA-KTHXJTJTSA-N
InChiInChI=1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13,23-24,26,38H,14H2,1-4H3,(H2,35,39)(H,36,40)(H,37,41)/t23-,24+,26+,31+/m0/s1
CAS Number1309684-94-3
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Ordering Information

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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
Solubility5mg/ml in DMSO 
Handling
Shipping ConditionShipped under ambient temperature. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

1673101 - RO8994 | CAS 1309684-94-3

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