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RAF265

Catalog No.: 122202
Cas No.: 927880-90-8
Purity : 98% 
122202 - RAF265 | CAS 927880-90-8

Catalog number : 122202

CAS number : 927880-90-8

Molecular Formula : C24H16F6N6O 

Molecular Weight : 518.41 

Iupac Chemical Name : 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine 

Smile : FC(C1=CC=C(NC3=NC2=CC(OC4=CC(C5=NC=C(C(F)(F)F)N5)=NC=C4)=CC=C2N3C)C=C1)(F)F

InChiKey : YABJJWZLRMPFSI-UHFFFAOYSA-N

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SynonymsCHIR-265; RAF 265; RAF-265; CHIR265 
Molecular FormulaC24H16F6N6O 
Molecular Weight518.41 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileFC(C1=CC=C(NC3=NC2=CC(OC4=CC(C5=NC=C(C(F)(F)F)N5)=NC=C4)=CC=C2N3C)C=C1)(F)F
InChiKeyYABJJWZLRMPFSI-UHFFFAOYSA-N
InChiInChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
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RAF265 is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. 

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