RAF265
Catalog No: 122202
CAS Number: 927880-90-8
Purity: 98%
RAF265 is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM.
For research use only. We do not sell to patients.
Chemical Information
| Name | RAF265 |
|---|---|
| Iupac Chemical Name | 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine |
| Synonyms | CHIR-265; RAF 265; RAF-265; CHIR265 |
| Molecular Formula | C24H16F6N6O |
| Molecular Weight | 518.41 |
| Smile | FC(C1=CC=C(NC3=NC2=CC(OC4=CC(C5=NC=C(C(F)(F)F)N5)=NC=C4)=CC=C2N3C)C=C1)(F)F |
| InChiKey | YABJJWZLRMPFSI-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) |
| CAS Number | 927880-90-8 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
