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R428

Catalog No.: 123010
Cas No.: 1037624-75-1
Purity : 98% 
123010 - R428 | CAS 1037624-75-1

Catalog number : 123010

CAS number : 1037624-75-1

Molecular Formula : C30H34N8 

Molecular Weight : 506.6450 

Iupac Chemical Name : 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine 

Smile : C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76

InChiKey : KXMZDGSRSGHMMK-UHFFFAOYSA-N

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SynonymsR-428; R 428 
Molecular FormulaC30H34N8 
Molecular Weight506.6450 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
InChiKeyKXMZDGSRSGHMMK-UHFFFAOYSA-N
InChiInChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)
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R428 is a potent and selective small-molecule inhibitor(IC50=14 nM), blocks the activities of Axl. 

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