Q-VD-OPH
Catalog No: 16071010
CAS Number: 1135695-98-5
Purity: 98% by HPLC
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). It protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
For research use only. We do not sell to patients.
Chemical Information
| Name | Q-VD-OPH |
|---|---|
| Iupac Chemical Name | (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-Methyl-1-oxo-2-[(2-quinolinylcarbonyl)aMino]butyl]aMino]-4-oxo-pentanoic Acid |
| Synonyms | Q-VD-OPH |
| Molecular Formula | C26H25F2N3O6 |
| Molecular Weight | 513.8 |
| Smile | FC1=C(OCC([C@H](CC(=O)O)NC([C@H](C(C)C)NC(=O)C2=NC3=CC=CC=C3C=C2)=O)=O)C(=CC=C1)F |
| InChiKey | OOBJCYKITXPCNS-REWPJTCUSA-N |
| InChi | InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1 |
| CAS Number | 1135695-98-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
