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Ponesimod

Catalog No: 17030918
CAS Number: 854107-55-4
Purity: 98% 

Ponesimod, also known as ACT-128800, is a potent, and orally active selective S1P(1) agonist. Ponesimod activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity. Ponesimod prevented edema formation, inflammatory cell accumulation, and cytokine release in the skin of mice with delayed-type hypersensitivity. Ponesimod also prevented the increase in paw volume and joint inflammation in rats with adjuvant-induced arthritis. Ponesimod may represent a new therapeutic approach in lymphocyte-mediated autoimmune diseases. 

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Chemical Information

NamePonesimod
Iupac Chemical Name(Z)-5-((Z)-3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one 
SynonymsACT-128800; ACT 128800; ACT128800; Ponesimod 
Molecular FormulaC23H25ClN2O4S 
Molecular Weight460.97 
SmileClC=1C=C(\C=C/2\C(N(/C(/S2)=N/CCC)C2=C(C=CC=C2)C)=O)C=CC1OC[C@@H](CO)O
InChiKeyLPAUOXUZGSBGDU-STDDISTJSA-N
InChiInChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1
CAS Number854107-55-4
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Ordering Information

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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17030918 - Ponesimod | CAS 854107-55-4

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