Ponatinib HCl
Catalog No.: 17030607
Cas No.: 1114544-31-8
Purity : 98%
Catalog number : 17030607
CAS number : 1114544-31-8
Molecular Formula : C29H28ClF3N6O
Molecular Weight : 569.0292
Iupac Chemical Name : 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
Smile : Cl.N=1C=C(N2N=CC=CC21)C#CC=2C=C(C(=O)NC1=CC(=C(C=C1)CN1CCN(CC1)C)C(F)(F)F)C=CC2C
InChiKey : BWTNNZPNKQIADY-UHFFFAOYSA-N
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry |
| Synonyms | AP24534; AP-24534; AP 24534; Ponatinib HCl; Ponatinib hydrochloride. trade name Iclusig |
|---|---|
| Molecular Formula | C29H28ClF3N6O |
| Molecular Weight | 569.0292 |
| Appearance | off-white solid |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20ºCpowder |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| Smile | Cl.N=1C=C(N2N=CC=CC21)C#CC=2C=C(C(=O)NC1=CC(=C(C=C1)CN1CCN(CC1)C)C(F)(F)F)C=CC2C |
| InChiKey | BWTNNZPNKQIADY-UHFFFAOYSA-N |
| InChi | InChI=1S/C29H27F3N6O.ClH/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37;/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);1H |
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Ponatinib, also known as AP24534 is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosomeCpositive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors. Ponatinib was approved in 2012.
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