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Pamiparib

Catalog No.: 512195
Cas No.: 1446261-44-4
Purity : 98% Min.
512195 - Pamiparib | CAS 1446261-44-4

Catalog number : 512195

CAS number : 1446261-44-4

Molecular Formula : C16H15FN4O

Molecular Weight : 298.31

Iupac Chemical Name : (10aR)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11- tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one

Smile : O=C1NN=C2CN(CCC3)[C@@]3(C)C(N4)=C2C5=C4C=C(F)C=C51

InChiKey : DENYZIUJOTUUNY-MRXNPFEDSA-N

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SynonymsPamiparib;BGB-290;BGB290
Molecular FormulaC16H15FN4O
Molecular Weight298.31
Appearancepale yellow solid
Purity98% Min.
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileO=C1NN=C2CN(CCC3)[C@@]3(C)C(N4)=C2C5=C4C=C(F)C=C51
InChiKeyDENYZIUJOTUUNY-MRXNPFEDSA-N
InChiInChI=1S/C16H15FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6,18H,2-4,7H2,1H3,(H,20,22)/t16-/m1/s1
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Pamiparib is an antineoplastic drug candidate. Pamiparib (BGB-290) is an investigational small molecule inhibitor of PARP1 and PARP2. Pamiparib is being evaluated as a monotherapy in pivotal clinical trials in China in recurrent platinum-sensitive and BRCA1/2 mutated ovarian cancers. It is currently in global clinical development as a monotherapy, and in combination with other agents, including BeiGene’s investigational anti-PD1 antibody, tislelizumab (BGB-A317), for a variety of solid tumor malignancies.

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