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Paltusotine ( CRN-00808 )

Catalog No.: 20294
Cas No.: 2172870-89-0
Purity : ≧98.0%

Paltusotine is a new class of oral, selective, nonpeptide, somatostatin receptor type 2 (SST2) agonists designed for the treatment of acromegaly.

For research use only. We do not sell to patients.

Chemical Information

NamePaltusotine ( CRN-00808 )
Iupac Chemical Name3-[4-(4-aminopiperidin-1-yl)-3-(3,5- difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
SynonymsPaltusotine ; CRN00808 ; CRN-00808 ; CRN 00808 ;
Molecular FormulaC27H22F2N4O
Molecular Weight456.49
SmileN#CC1=CC=CC(C2=CC=C3N=CC(C4=CC(F)=CC(F)=C4)=C(N5CCC(N)CC5)C3=C2)=C1O
InChiKeyGHILNKWBALQPDP-UHFFFAOYSA-N
InChiInChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
CAS Number2172870-89-0
Related CAS2361216-83-1 (HCl) ; 2172870-89-0 (free base) ; 2172875-40-8 (2HCl)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationSolid powder
Purity≧98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingRefer to MSDS operation
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code2934200090
Coming soon.
TargetsORAL SST2 AGONIST
Mechanism
Cell study
Animal study
Clinical study

[1]. Murray B. Gordon, et al. Identification of a dose range for once daily oral paltusotine in patients with acromegaly that maintains IGF-1 levels when switching from long-acting somatostatin receptor ligand therapy. Endocrine Abstracts (2021) 73 OC15.4.


[2]. Rosa Luo, et al. Pharmacokinetics and Safety of an Improved Oral Formulation of Paltusotine, a Selective, Non-Peptide Somatostatin Receptor 2 (SST2) Agonist for the Treatment of Acromegaly. Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021.


Chemical Structure

20294 - Paltusotine ( CRN-00808 ) | CAS 2172870-89-0

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