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PTI-428(PTI428)

Catalog No.: 512196
Cas No.: 1953130-87-4
Purity : 98% Min.
512196 - PTI-428(PTI428) | CAS 1953130-87-4

Catalog number : 512196

CAS number : 1953130-87-4

Molecular Formula : C18H18N4O4

Molecular Weight : 354.36

Iupac Chemical Name : N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide, N-(trans-3-(5-((R)-1-hydroxyethyl)-1,3,4-oxadiazol-2-yl)cyclobutyl)-3-phenylisoxazole-5-carboxamide

Smile : O=C(C1=CC(C2=CC=CC=C2)=NO1)N[C@H]3C[C@H](C4=NN=C([C@H](O)C)O4)C3

InChiKey : XPEHHUISIBFLHX-RAIGVLPGSA-N

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SynonymsPTI-428, PTI428
Molecular FormulaC18H18N4O4
Molecular Weight354.36
AppearanceOff-white solid to white solid
Purity98% Min.
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature 
SmileO=C(C1=CC(C2=CC=CC=C2)=NO1)N[C@H]3C[C@H](C4=NN=C([C@H](O)C)O4)C3
InChiKeyXPEHHUISIBFLHX-RAIGVLPGSA-N
InChiInChI=1S/C18H18N4O4/c1-10(23)17-20-21-18(25-17)12-7-13(8-12)19-16(24)15-9-14(22-26-15)11-5-3-2-4-6-11/h2-6,9-10,12-13,23H,7-8H2,1H3,(H,19,24)/t10-,12-,13-/m1/s1

PTI-428 is a type of CFTR modulator called an amplifier. Amplifiers increase the amount of CFTR protein in the cell. This makes more CFTR protein available for other therapies to work on. When combined with other therapies, PTI-428 may increase CFTR function across multiple gene mutations.

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