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PRX-08066

Catalog No.: 16071114
Cas No.: 866206-54-4
Purity : 98% by HPLC 
16071114 - PRX-08066 | CAS 866206-54-4

Catalog number : 16071114

CAS number : 866206-54-4

Molecular Formula : C19H17ClFN5S 

Molecular Weight : 401.8884 

Iupac Chemical Name : 5-((4-(6-Chlorothieno(2,3-d)pyrimidine-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile 

Smile : ClC1=CC2=C(N=CN=C2NC2CCN(CC2)CC=2C=CC(=C(C#N)C2)F)S1

InChiKey : IENZFHBNCRQMNP-UHFFFAOYSA-N

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SynonymsPRX-08066; PRX 08066 
Molecular FormulaC19H17ClFN5S 
Molecular Weight401.8884 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileClC1=CC2=C(N=CN=C2NC2CCN(CC2)CC=2C=CC(=C(C#N)C2)F)S1
InChiKeyIENZFHBNCRQMNP-UHFFFAOYSA-N
InChiInChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)
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PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5-HT(2B) expressing SI-NET cell line, KRJ-I, PRX-08066 inhibited proliferation (IC(50) 4.6 x 10(-9)M) and 5-HT secretion (6.9 x 10(-9)M) and decreased ERK1/2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1], connective tissue growth factor [CTGF] and fibroblast growth factor [FGF2]). 

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