PLX-4545
Catalog No: 24111
CAS Number: 2892065-45-9
Purity: ≧98.0%
PLX-4545 is an orally bioavailable molecular glue degrader of IKZF2 designed to destabilize highly suppressive regulatory T cells.
For research use only. We do not sell to patients.
Chemical Information
| Name | PLX-4545 |
|---|---|
| Iupac Chemical Name | (S)-3-(1-oxo-5-(((1S,2S)-2-(3-phenylazetidin-1-yl)cyclohexyl)oxy)isoindolin-2-yl)piperidine-2,6-dione |
| Synonyms | PLX 4545 ; PLX4545 |
| Molecular Formula | C28H31N3O4 |
| Molecular Weight | 473.57 |
| Smile | O=C1CC[C@H](N2CC3=C(C=CC(O[C@H]4CCCC[C@@H]4N5CC(C6=CC=CC=C6)C5)=C3)C2=O)C(N1)=O |
| InChiKey | DQYZQRGRHXEYPT-SDHOMARFSA-N |
| InChi | InChI=1S/C28H31N3O4/c32-26-13-12-24(27(33)29-26)31-17-19-14-21(10-11-22(19)28(31)34)35-25-9-5-4-8-23(25)30-15-20(16-30)18-6-2-1-3-7-18/h1-3,6-7,10-11,14,20,23-25H,4-5,8-9,12-13,15-17H2,(H,29,32,33)/t23-,24-,25-/m0/s1 |
| CAS Number | 2892065-45-9 |
| Related CAS | 2892065-45-9 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
