PI-103
Catalog No: 160926002
CAS Number: 371935-74-9
Purity: 97% by HPLC
It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 M. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 l) solution of PI-103 in DMSO is also available.
For research use only. We do not sell to patients.
Chemical Information
| Name | PI-103 |
|---|---|
| Iupac Chemical Name | 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol |
| Synonyms | 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V |
| Molecular Formula | C19H16N4O3 |
| Molecular Weight | 348.4 |
| Smile | N1(CCOCC1)C=1C2=C(N=C(N1)C=1C=C(C=CC1)O)C1=C(O2)N=CC=C1 |
| InChiKey | TUVCWJQQGGETHL-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 |
| CAS Number | 371935-74-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 97% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
