PFM01
PFM01 is a nuclease-specific MRE11 inhibitor. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling.
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Chemical Information
| Name | PFM01 |
|---|---|
| Iupac Chemical Name | (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone |
| Synonyms | PFM01; PFM-01; PFM 01. |
| Molecular Formula | C14H15NO2S2 |
| Molecular Weight | 293.40 |
| Smile | O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S |
| InChiKey | GPURHDUTZUYAFI-GHXNOFRVSA-N |
| InChi | InChI=1S/C14H15NO2S2/c1-9(2)8-15-13(17)12(19-14(15)18)7-10-3-5-11(16)6-4-10/h3-7,9,16H,8H2,1-2H3/b12-7- |
| CAS Number | 1558598-41-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Purity | 98% Min. |
|---|---|
| Handling | |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van
Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale
MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA. DNA double-strand break
repair pathway choice is directed by distinct MRE11 nuclease activities. Mol
Cell. 2014 Jan 9;53(1):7-18. doi: 10.1016/j.molcel.2013.11.003. Erratum in: Mol
Cell. 2014 Jan 23;53(2):361. PubMed PMID: 24316220; PubMed Central PMCID:
PMC3909494.
Chemical Structure
