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PF-4989216

Catalog No.: 161009002
Cas No.: 1276553-09-3
Purity : 98% by HPLC 

PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation. 

For research use only. We do not sell to patients.

Chemical Information

NamePF-4989216
Iupac Chemical Name4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile 
SynonymsPF4989216; PF 4989216; PF-4989216. 
Molecular FormulaC18H13FN6OS 
Molecular Weight380.39882 
SmileC(#N)C1=CC(=C(C=C1)C=1C(=C(SC1C1=NC=NN1)N1CCOCC1)C#N)F
InChiKeyMUENOTXSRZEFJV-UHFFFAOYSA-N
InChiInChI=1S/C18H13FN6OS/c19-14-7-11(8-20)1-2-12(14)15-13(9-21)18(25-3-5-26-6-4-25)27-16(15)17-22-10-23-24-17/h1-2,7,10H,3-6H2,(H,22,23,24)
CAS Number1276553-09-3
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

161009002 - PF-4989216 | CAS 1276553-09-3

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