PF-4989216
Catalog No: 161009002
CAS Number: 1276553-09-3
Purity: 98% by HPLC
PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.
For research use only. We do not sell to patients.
Chemical Information
| Name | PF-4989216 |
|---|---|
| Iupac Chemical Name | 4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile |
| Synonyms | PF4989216; PF 4989216; PF-4989216. |
| Molecular Formula | C18H13FN6OS |
| Molecular Weight | 380.39882 |
| Smile | C(#N)C1=CC(=C(C=C1)C=1C(=C(SC1C1=NC=NN1)N1CCOCC1)C#N)F |
| InChiKey | MUENOTXSRZEFJV-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H13FN6OS/c19-14-7-11(8-20)1-2-12(14)15-13(9-21)18(25-3-5-26-6-4-25)27-16(15)17-22-10-23-24-17/h1-2,7,10H,3-6H2,(H,22,23,24) |
| CAS Number | 1276553-09-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
