PF-06802861 ( ARRY 371797 ; ARRY-797 )
Catalog No: 2073108
CAS Number: 1034189-82-6
Purity: ≧98.0%
ARRY 797 (also known as ARRY 371797 or PF 06802861) is an orally active, selective p38 mitogen-activated protein kinase inhibitor of p38alpha enzyme (IC50<5 nM). ARRY-797 is being studied in a Phase 3 trial in patients with lamin A/C-related dilated cardiomyopathy (LMNA-related DCM), a rare, degenerative cardiovascular disease caused by mutations in the LMNA gene and characterized by poor prognosis.
PF-06802861 (ARRY 371797;ARRY-797), contact us by email for the Bulk quotation.
For research use only. We do not sell to patients.
Chemical Information
| Name | PF-06802861 ( ARRY 371797 ; ARRY-797 ) |
|---|---|
| Iupac Chemical Name | 5-(2,4-difluoro-phenoxy)-1-isobutyl-1H-indazole-6-carboxylic acid (2-dimethylamino-ethyl)-amide |
| Synonyms | ARRY-371797 ; ARRY 371797 ; ARRY371797 ; ARRY-797 ; ARRY 797 ; ARRY797 ; PF-06802861 ; PF06802861 ; PF 06802861 |
| Molecular Formula | 416.46 |
| Molecular Weight | C22H26F2N4O2 |
| Smile | O=C(C1=CC2=C(C=C1OC3=CC=C(F)C=C3F)C=NN2CC(C)C)NCCN(C)C |
| InChiKey | IFGWYHGYNVGVRB-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H26F2N4O2/c1-14(2)13-28-19-11-17(22(29)25-7-8-27(3)4)21(9-15(19)12-26-28)30-20-6-5-16(23)10-18(20)24/h5-6,9-12,14H,7-8,13H2,1-4H3,(H,25,29) |
| CAS Number | 1034189-82-6 |
| Related CAS | 1034189-82-6 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
| Targets | p38 MAPK inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | Phase 3 trial |
Not available
Chemical Structure
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