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PF-05089771

Catalog No.: 17030912
Cas No.: 1235403-62-9
Purity : 98% 
17030912 - PF-05089771 | CAS 1235403-62-9

Catalog number : 17030912

CAS number : 1235403-62-9

Molecular Formula : C18H12Cl2FN5O3S2 

Molecular Weight : 500.3444 

Iupac Chemical Name : 4-(2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide 

Smile : NC1=C(C=NN1)C1=C(OC2=CC(=C(C=C2Cl)S(=O)(=O)NC=2N=CSC2)F)C=CC(=C1)Cl

InChiKey : ZYSCOUXLBXGGIM-UHFFFAOYSA-N

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SynonymsPF-05089771; PF 05089771; PF05089771; PF-05089771; PF05089771; PF 05089771 
Molecular FormulaC18H12Cl2FN5O3S2 
Molecular Weight500.3444 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileNC1=C(C=NN1)C1=C(OC2=CC(=C(C=C2Cl)S(=O)(=O)NC=2N=CSC2)F)C=CC(=C1)Cl
InChiKeyZYSCOUXLBXGGIM-UHFFFAOYSA-N
InChiInChI=1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25)
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PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a slow onset of block that is depolarization and concentration dependent, with a similarly slow recovery from block.

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