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P5091 (P005091)

Catalog No.: 16122795
Cas No.: 882257-11-6
Purity : 98% 
16122795 - P5091 (P005091) | CAS 882257-11-6

Catalog number : 16122795

CAS number : 882257-11-6

Molecular Formula : C12H7Cl2NO3S2 

Molecular Weight : 348.22 

Iupac Chemical Name : P5091 (P005091) 

Smile : CC(=O)c1cc(c(s1)Sc2cccc(c2Cl)Cl)[N+](=O)[O-]

InChiKey : LKZLGMAAKNEGCH-UHFFFAOYSA-N

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SynonymsN/A 
Molecular FormulaC12H7Cl2NO3S2 
Molecular Weight348.22 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(=O)c1cc(c(s1)Sc2cccc(c2Cl)Cl)[N+](=O)[O-]
InChiKeyLKZLGMAAKNEGCH-UHFFFAOYSA-N
InChiInChI=1S/C12H7Cl2NO3S2/c1-6(16)10-5-8(15(17)18)12(20-10)19-9-4-2-3-7(13)11(9)14/h2-5H,1H3
MDLMFCD00123202
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P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 M and the closely related USP47.P5091 is a trisubstituted thiophene with dichlorophenylthio, nitro, and acetyl substituents mediating anti-USP7 activity. P5091 exhibits potent, specific, and selective deubiquitylating activity against USP7. In contrast, P5091 does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). P5091 inhibits the labeling of USP7 with HA-UbVME in a concentration-dependent manner. USP7-mediated cleavage of high molecular weight polyubiquitin chains is inhibited in a dose-dependent manner by P5091. 

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