P5091 (P005091)
Catalog No: 16122795
CAS Number: 882257-11-6
Purity: 98%
P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 M and the closely related USP47.P5091 is a trisubstituted thiophene with dichlorophenylthio, nitro, and acetyl substituents mediating anti-USP7 activity. P5091 exhibits potent, specific, and selective deubiquitylating activity against USP7. In contrast, P5091 does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). P5091 inhibits the labeling of USP7 with HA-UbVME in a concentration-dependent manner. USP7-mediated cleavage of high molecular weight polyubiquitin chains is inhibited in a dose-dependent manner by P5091.
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Chemical Information
| Name | P5091 (P005091) |
|---|---|
| Iupac Chemical Name | P5091 (P005091) |
| Synonyms | N/A |
| Molecular Formula | C12H7Cl2NO3S2 |
| Molecular Weight | 348.22 |
| Smile | CC(=O)c1cc(c(s1)Sc2cccc(c2Cl)Cl)[N+](=O)[O-] |
| InChiKey | LKZLGMAAKNEGCH-UHFFFAOYSA-N |
| InChi | InChI=1S/C12H7Cl2NO3S2/c1-6(16)10-5-8(15(17)18)12(20-10)19-9-4-2-3-7(13)11(9)14/h2-5H,1H3 |
| CAS Number | 882257-11-6 |
| MDL | MFCD00123202 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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