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OTS964

Catalog No.: 51507
Cas No.: 1338545-07-5
Purity : 98% 

TOPK (TClymphokine-activated killer cellCoriginated protein kinase) is highly and frequently transactivated in various cancer tissues, including lung and triple-negative breast cancers, and plays an indispensable role in the mitosis of cancer cells. OTS964 is a potent TOPK inhibitor, which inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration of the free compound induced hematopoietic adverse reactions (leukocytopenia associated with thrombocytosis), the drug delivered in a liposomal formulation effectively caused complete regression of transplanted tumors without showing any adverse reactions in mice. The esults suggest that the inhibition of TOPK activity may be a viable therapeutic option for the treatment of various human cancers.



 

 

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Chemical Information

NameOTS964
Iupac Chemical Name(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one 
SynonymsOTS964; OTS-964; OTS 964. 
Molecular FormulaC22H22N2O2S 
Molecular Weight378.49 
SmileC[C@H](C1=CC=C(C=C1)C2=C(C=CC3=C2C4=C(C(N3)=O)SC=C4)O)CN(C)C
InChiKeyWGYWHJPQFQGLOQ-ZDUSSCGKSA-N
InChiInChI=1S/C22H22N2O2S/c1-13(12-24(2)3)14-4-6-15(7-5-14)19-18(25)9-8-17-20(19)16-10-11-27-21(16)22(26)23-17/h4-11,13,25H,12H2,1-3H3,(H,23,26)/t13-/m0/s1
CAS Number1338545-07-5
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

51507 - OTS964 | CAS 1338545-07-5

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