ON 146040
ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K / isoforms with IC50 of 14/20 nM.
ON 146040 was highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. In biochemical testing, ON 146040 inhibited PI3K / isoforms (IC50 14 and 20 nM, respectively) without having a major effect on / isoforms (IC50 3 and 1 M, respectively). ON 146040 was also found to inhibit Abl1 and several mutant versions of this kinase (IC50 < 150 nM), although the compound was not found to be active against the T315I mutant. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation were down-regulated in leukemia and myeloma cells.
For research use only. We do not sell to patients.
Chemical Information
| Name | ON 146040 |
|---|---|
| Iupac Chemical Name | LY3023414 |
| Synonyms | ON-146040; ON146040 |
| Molecular Formula | C24H23N7O3S |
| Molecular Weight | 489.55 |
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| InChi | |
| CAS Number | 1404231-34-0 |
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Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
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Chemical Structure
