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ON 146040

Catalog No.: 611901
Cas No.: 1404231-34-0
Purity : 98% 

ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K / isoforms with IC50 of 14/20 nM. 


ON 146040 was highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. In biochemical testing, ON 146040 inhibited PI3K / isoforms (IC50  14 and 20 nM, respectively) without having a major effect on / isoforms (IC50  3 and 1 M, respectively). ON 146040 was also found to inhibit Abl1 and several mutant versions of this kinase (IC50 < 150 nM), although the compound was not found to be active against the T315I mutant. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation were down-regulated in leukemia and myeloma cells.


 

For research use only. We do not sell to patients.

Chemical Information

NameON 146040
Iupac Chemical NameLY3023414 
SynonymsON-146040; ON146040 
Molecular FormulaC24H23N7O3S 
Molecular Weight489.55 
InChiKey
InChi
CAS Number1404231-34-0
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

611901 - ON 146040 | CAS 1404231-34-0

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