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ONT-093

Catalog No.: 17030901
Cas No.: 216227-54-2
Purity : 98% 
17030901 - ONT-093 | CAS 216227-54-2

Catalog number : 17030901

CAS number : 216227-54-2

Molecular Formula : C32H38N4O 

Molecular Weight : 494.67 

Iupac Chemical Name : (E)-4,4'-(2-(4-(3-ethoxyprop-1-en-1-yl)phenyl)-1H-imidazole-4,5-diyl)bis(N-isopropylaniline) 

Smile : C(C)OC/C=C/C1=CC=C(C=C1)C=1NC(=C(N1)C1=CC=C(NC(C)C)C=C1)C1=CC=C(NC(C)C)C=C1

InChiKey : RSJCLODJSVZNQA-BQYQJAHWSA-N

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SynonymsONT-093; ONT 093; ONT093; OC-144-093; OC 144-093; OC144-093; OC-144093; OC 144093; OC144093 
Molecular FormulaC32H38N4O 
Molecular Weight494.67 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC(C)OC/C=C/C1=CC=C(C=C1)C=1NC(=C(N1)C1=CC=C(NC(C)C)C=C1)C1=CC=C(NC(C)C)C=C1
InChiKeyRSJCLODJSVZNQA-BQYQJAHWSA-N
InChiInChI=1S/C32H38N4O/c1-6-37-21-7-8-24-9-11-27(12-10-24)32-35-30(25-13-17-28(18-14-25)33-22(2)3)31(36-32)26-15-19-29(20-16-26)34-23(4)5/h7-20,22-23,33-34H,6,21H2,1-5H3,(H,35,36)/b8-7+
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ONT-093, also known as OC-144-093, is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.

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