OICR-9429
Catalog No: 6111010
CAS Number: 1801787-56-3
Purity: 98%
OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N-terminal C/EBP mutations by about 50% (mean value, n = 8) at 5 M [2] In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.
For research use only. We do not sell to patients.
Chemical Information
| Name | OICR-9429 |
|---|---|
| Iupac Chemical Name | OICR-9429 |
| Synonyms | OICR9429, OICR 9429 |
| Molecular Formula | C29H32F3N5O3 |
| Molecular Weight | 555.59 |
| InChiKey | |
| InChi | |
| CAS Number | 1801787-56-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
