OATD-01 (GLPG-4716)
Catalog No: 208191
CAS Number: 2088453-21-6
Purity: ≧98.0%
OATD-01 (GLPG-4716) 是一种有效的酸性哺乳动物几丁质酶（AMCase）和壳三糖苷酶（CHIT1）双重抑制剂，hAMCase IC50 = 9nM，hCHIT1 IC50 = 26nM，m AMCase IC50 = 8nM，hCHIT1 IC50 = 29nM。 OATD-01可以显着改善博来霉素诱导的小鼠模型中的肺纤维化。 OATD-01是针对几丁质酶家族成员的第一个进入临床研究的候选药物。
For research use only. We do not sell to patients.
Chemical Information
| Name | OATD-01 (GLPG-4716) |
|---|---|
| Iupac Chemical Name | 5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine |
| Synonyms | OATD-01; OATD 01; OATD01; GLPG 4716 ; GLPG 4716 ; GLPG4716 ; OAT-889 ; OAT889 ; OAT 889 |
| Molecular Formula | C19H27ClN6O |
| Molecular Weight | 390.91 |
| Smile | NC1=NNC(N2CCC(N3C[C@H](C)OC[C@@H]3CC4=CC=C(Cl)C=C4)CC2)=N1 |
| InChiKey | STWVLEKJQQRGMO-GUYCJALGSA-N |
| InChi | InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1 |
| CAS Number | 2088453-21-6 |
| Related CAS | 2088453-21-6 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | 类白色至白色固体 |
|---|---|
| Purity | ≧98.0% |
| Storage | 短期可在0-4度保存，数天至数月；长期可在-20度保存三年。 |
| Solubility | 可溶于DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | 可在常温下运输 |
| HS Code |
Coming soon.
| Targets | Dual Chitinase Inhibitor |
|---|---|
| Mechanism | OATD-01 is a potent dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with hAMCase IC50=9nM, hCHIT1 IC50=26nM, m AMCase IC50=8nM, hCHIT1 IC50=29nM. |
| Cell study | |
| Animal study | |
| Clinical study | Phase 1 Clinical Trial |
Not available
Chemical Structure
