OATD-01
Catalog No.: 208191
Cas No.: 2088453-21-6
Purity : ≧98.0%
OATD-01，Bulk in stock，contact us by email for the Bulk quotation.
OATD-01 is a potent dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with hAMCase IC50=9nM, hCHIT1 IC50=26nM, m AMCase IC50=8nM, hCHIT1 IC50=29nM. OATD-01 Significantly Ameliorates Pulmonary Fibrosis in the Bleomycin-Induced Mouse Model. OATD-01 is the first drug candidate targeting members of the chitinase family to enter clinical development.
For research use only. We do not sell to patients.
Chemical Information
| Name | OATD-01 |
|---|---|
| Iupac Chemical Name | 5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine |
| Synonyms | OATD-01; OATD 01; OATD01; |
| Molecular Formula | C19H27ClN6O |
| Molecular Weight | 390.91 |
| Smile | NC1=NNC(N2CCC(N3C[C@H](C)OC[C@@H]3CC4=CC=C(Cl)C=C4)CC2)=N1 |
| InChiKey | STWVLEKJQQRGMO-GUYCJALGSA-N |
| InChi | InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1 |
| CAS Number | 2088453-21-6 |
| Related CAS | 2088453-21-6 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | Dual Chitinase Inhibitor |
|---|---|
| Mechanism | OATD-01 is a potent dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with hAMCase IC50=9nM, hCHIT1 IC50=26nM, m AMCase IC50=8nM, hCHIT1 IC50=29nM. |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
