OATD-01 (GLPG-4716)
Catalog No: 208191
CAS Number: 2088453-21-6
Purity: ≧98.0%
OATD-01 (GLPG-4716), a dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1), is in early clinical trials at Molecure (formerly OncoArendi Therapeutics) for the oral treatment of diseases with a fibrotic component such as idiopathic pulmonary fibrosis (IPF) and sarcoidosis.
In 2020, OncoArendi Therapeutics granted the global rights of development and commercialization to Galapagos. In 2022, Galapagos returned all product rights.
The compound was granted orphan drug designation in the U.S. for the treatment of IPF and for the treatment of sarcoidosis in 2019 and 2020, respectively.
For research use only. We do not sell to patients.
Chemical Information
| Name | OATD-01 (GLPG-4716) |
|---|---|
| Iupac Chemical Name | 5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine |
| Synonyms | OATD-01; OATD 01; OATD01; GLPG 4716 ; GLPG 4716 ; GLPG4716 ; OAT-889 ; OAT889 ; OAT 889 |
| Molecular Formula | C19H27ClN6O |
| Molecular Weight | 390.91 |
| Smile | NC1=NNC(N2CCC(N3C[C@H](C)OC[C@@H]3CC4=CC=C(Cl)C=C4)CC2)=N1 |
| InChiKey | STWVLEKJQQRGMO-GUYCJALGSA-N |
| InChi | InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1 |
| CAS Number | 2088453-21-6 |
| Related CAS | 2088453-21-6 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | Dual Chitinase Inhibitor |
|---|---|
| Mechanism | OATD-01 is a potent dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with hAMCase IC50=9nM, hCHIT1 IC50=26nM, m AMCase IC50=8nM, hCHIT1 IC50=29nM. |
| Cell study | |
| Animal study | |
| Clinical study | Phase 1 Clinical Trial |
Not available
Chemical Structure
