Welcome to Sun-shine chemical
+86-17702719238 sales@sun-shinechem.com

OATD-01 (GLPG-4716)

Catalog No: 208191
CAS Number: 2088453-21-6
Purity: ≧98.0%

OATD-01 (GLPG-4716), a dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1), is in early clinical trials at Molecure (formerly OncoArendi Therapeutics) for the oral treatment of diseases with a fibrotic component such as idiopathic pulmonary fibrosis (IPF) and sarcoidosis. In 2020, OncoArendi Therapeutics granted the global rights of development and commercialization to Galapagos. In 2022, Galapagos returned all product rights. The compound was granted orphan drug designation in the U.S. for the treatment of IPF and for the treatment of sarcoidosis in 2019 and 2020, respectively.

For research use only. We do not sell to patients.

Chemical Information

NameOATD-01 (GLPG-4716)
Iupac Chemical Name5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine
SynonymsOATD-01; OATD 01; OATD01; GLPG 4716 ; GLPG 4716 ; GLPG4716 ; OAT-889 ; OAT889 ; OAT 889
Molecular FormulaC19H27ClN6O
Molecular Weight390.91
CAS Number2088453-21-6
Related CAS2088453-21-6

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationOff-white solid to white solid
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
TargetsDual Chitinase Inhibitor
MechanismOATD-01 is a potent dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with hAMCase IC50=9nM, hCHIT1 IC50=26nM, m AMCase IC50=8nM, hCHIT1 IC50=29nM.
Cell study
Animal study
Clinical studyPhase 1 Clinical Trial
Not available

Chemical Structure

208191 - OATD-01 (GLPG-4716) | CAS 2088453-21-6

Quick Order