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Nolatrexed

Catalog No: 17030908
CAS Number: 147149-76-6
Purity: 98% 

Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Hence, it does not warrant further study as a single agent for this disease. 

For research use only. We do not sell to patients.

Chemical Information

NameNolatrexed
Iupac Chemical Name2-Amino-6-methyl-5-(4-pyridylthio)-1H-quinazolin-4-one dihydrochloride 
SynonymsAG337; AG 337; AG-337; Nolatrexed HCl; Nolatrexed dihydrochloride; brand name: Thymitaq 
Molecular FormulaC14H14Cl2N4OS 
Molecular Weight357.253 
SmileCl.Cl.NC=1NC2=CC=C(C(=C2C(N1)=O)SC1=CC=NC=C1)C
InChiKeyPJKVJJYMWOCLIJ-UHFFFAOYSA-N
InChiInChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
CAS Number147149-76-6
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Ordering Information

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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17030908 - Nolatrexed | CAS 147149-76-6

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