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Netarsudil(Mesylate)

Catalog No: 712181
CAS Number: 1422144-42-0
Purity: ≧98%

Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.

For research use only. We do not sell to patients.

Chemical Information

NameNetarsudil(Mesylate)
Iupac Chemical Name(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimethanesulfonate
SynonymsAR-13324; AR13324; AR 13324; Netarsudil Mesylate
Molecular FormulaC30H35N3O9S2
Molecular Weight645.74
SmileCS(=O)(O)=O.CS(=O)(O)=O.O=C(OCC1=CC=C([C@@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C
InChiKeyQQDRLKRHJOAQDC-FBHGDYMESA-N
InChiInChI=1S/C28H27N3O3.2CH4O3S/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;2*1-5(2,3)4/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H3,(H,2,3,4)/t26-;;/m1../s1
CAS Number1422144-42-0
Related CAS1422144-42-0 (mesylate) 1254032-66-0 (free base) 1253952-02-1 (HCl)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationlight-yellow solid to off-white solid 
Purity≧98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

712181 - Netarsudil(Mesylate) | CAS 1422144-42-0

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