Neflamapimod, also known as VX-745, VRT-031745 and VD-31745, is highly potent and selective p38α inhibitor (IC50 = 10 nM).
For research use only. We do not sell to patients.
Chemical Information
| Name | Neflamapimod |
| Iupac Chemical Name | 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyrimido[3,4-b]pyridazin-6-one |
| Synonyms | VX-745; VX 745; VX745; VRT-031745, VD-31745; Neflamapimod. |
| Molecular Formula | C19H9Cl2F2N3OS |
| Molecular Weight | 436.26 |
| Smile | ClC1=C(C(=CC=C1)Cl)C=1C(N=CN2N=C(C=CC21)SC2=C(C=C(C=C2)F)F)=O |
| InChiKey | VEPKQEUBKLEPRA-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H |
| CAS Number | 209410-46-8 |
| Related CAS | |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
| Bulk | | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
| Purity | 98.0% |
| Storage | -20 ℃ for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |