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Necrostatin 2 S enantiomer

Catalog No.: 6111412
Cas No.: 852391-20-9
Purity : 98% 
6111412 - Necrostatin 2 S enantiomer | CAS 852391-20-9

Catalog number : 6111412

CAS number : 852391-20-9

Molecular Formula : C13H12ClN3O2 

Molecular Weight : 277.71 

Iupac Chemical Name : Necrostatin 2 S enantiomer 

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SynonymsNecrostatin-2 S enantiomer 
Molecular FormulaC13H12ClN3O2 
Molecular Weight277.71 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.


Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).


 

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