NVL-655 ( ALK-IN-27 )
Catalog No: 24003
CAS Number: 2739866-40-9
Purity: ≧98.0%
NVL-655 is a novel, brain-penetrant, ALK-selective inhibitor that was designed to address the ongoing unmet needs that exist with currently available ALK inhibitors, including treatment resistance, brain metastases, and off-target central nervous system (CNS) adverse effects (AEs) related to TRK inhibition.
For research use only. We do not sell to patients.
Chemical Information
| Name | NVL-655 ( ALK-IN-27 ) |
|---|---|
| Iupac Chemical Name | (R)-1-chloro-3-ethyl-12-fluoro-10,16-dimethyl-3,10,16,18-tetrahydro-4,8-(metheno)benzo[l]dipyrazolo[3,4-g:4',3'-j][1]oxa[4]azacyclotetradecin-7-amine |
| Synonyms | NVL-655 ; ALK-IN-27 ; NVL655 ; NVL 655 |
| Molecular Formula | C23H22ClFN6O |
| Molecular Weight | 452.92 |
| Smile | CCN1C2=C(C(Cl)=N1)CC3=CN(C)N=C3C4=CC=C(F)C=C4[C@H](OC5=C(N)N=CC2=C5)C |
| InChiKey | FWZSCAQEBTVTOM-GFCCVEGCSA-N |
| InChi | InChI=1S/C23H22ClFN6O/c1-4-31-21-13-8-19(23(26)27-10-13)32-12(2)17-9-15(25)5-6-16(17)20-14(11-30(3)28-20)7-18(21)22(24)29-31/h5-6,8-12H,4,7H2,1-3H3,(H2,26,27)/t12-/m1/s1 |
| CAS Number | 2739866-40-9 |
| Related CAS | 2739866-40-9 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
.png)