NU 7026
Catalog No: 6118017
CAS Number: 154447-35-5
Purity: 98%
NU 7026 is a novel and potential inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK) with IC50 of 0.23 uM; displays selectivity over other PIKK family enzymes.
NU7026 treatment resulted in significant reduction in the number of H2AX foci after -irradiation in wild-type cells, but had no significant effect in RIC1 cells .NU7026 underwent rapid plasma clearance (0.108 l h(-1)) and this was largely attributed to extensive metabolism. Bioavailability following interperitoneal (i.p.) and p.o. administration at 20 mg kg(-1) was 20 and 15%, respectively .
For research use only. We do not sell to patients.
Chemical Information
| Name | NU 7026 |
|---|---|
| Iupac Chemical Name | NU 7026 |
| Synonyms | LY293646; NU7026; NU-7026; LY 293646; LY-293646 |
| Molecular Formula | C17H15NO3 |
| Molecular Weight | 281.31 |
| Smile | c1ccc2c(c1)ccc3c2oc(cc3=O)N4CCOCC4 |
| InChiKey | KKTZALUTXUZPSN-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2 |
| CAS Number | 154447-35-5 |
| MDL | MFCD06798345 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
