NST-628
Catalog No: 24058
CAS Number: 3002056-30-3
Purity: ≧98.0%
NST-628 is a potent pan-RAF-MEK molecular glue that prevents the phosphorylation and activation of MEK by RAF, overcoming the limitations of traditional RAS-MAPK inhibitors and leading to deep durable inhibition of the pathway.
For research use only. We do not sell to patients.
Chemical Information
| Name | NST-628 |
|---|---|
| Iupac Chemical Name | 3-[[3-fluoro-2-(methylsulfamoylamino)-4-pyridyl]methyl]-7-[(3-fluoro-2-pyridyl)oxy]-4-methylchromen-2-one |
| Synonyms | NST-628 ; NST628 ; NST 628 |
| Molecular Formula | C22H18F2N4O5S |
| Molecular Weight | 488.47 |
| Smile | O=C1C(CC2=C(F)C(NS(=O)(NC)=O)=NC=C2)=C(C)C3=C(O1)C=C(OC4=NC=CC=C4F)C=C3 |
| InChiKey | YQSZJOABXRROQR-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H18F2N4O5S/c1-12-15-6-5-14(32-21-17(23)4-3-8-27-21)11-18(15)33-22(29)16(12)10-13-7-9-26-20(19(13)24)28-34(30,31)25-2/h3-9,11,25H,10H2,1-2H3,(H,26,28) |
| CAS Number | 3002056-30-3 |
| Related CAS | 3002056-30-3 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
