NSD1 inhibitor BT5
Catalog No: 25207
CAS Number: 2351225-46-0
Purity: ≧98.0%
BT5 potently inhibits NSD1, engages the SET domain in cells, and reduces H3K36me2 levels. Additionally, BT5 inhibited growth of NUP98-NSD1-transformed cells and demonstrated on-target activity through downregulated HoxA genes.
For research use only. We do not sell to patients.
Chemical Information
| Name | NSD1 inhibitor BT5 |
|---|---|
| Iupac Chemical Name | 2-amino-6-(2-methylaziridin-1-yl)benzo[d]thiazol-4-ol |
| Synonyms | NSD1 inhibitor BT5 |
| Molecular Formula | C10H11N3OS |
| Molecular Weight | 221.06 |
| Smile | OC1=C2N=C(N)SC2=CC(N3C(C)C3)=C1 |
| InChiKey | PHBIAWCGMOCBGF-UHFFFAOYSA-N |
| InChi | InChI=1S/C10H11N3OS/c1-5-4-13(5)6-2-7(14)9-8(3-6)15-10(11)12-9/h2-3,5,14H,4H2,1H3,(H2,11,12) |
| CAS Number | 2351225-46-0 |
| Related CAS | 2351225-46-0 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | NSD1 inhibitor |
|---|---|
| Mechanism | BT5 potently inhibits NSD1, engages the SET domain in cells, and reduces H3K36me2 levels. Additionally, BT5 inhibited growth of NUP98-NSD1-transformed cells and demonstrated on-target activity through downregulated HoxA genes. |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
