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NSC697923

Catalog No.: 16122791
Cas No.: 343351-67-7
Purity : 98% 
16122791 - NSC697923 | CAS 343351-67-7

Catalog number : 16122791

CAS number : 343351-67-7

Molecular Formula : C11H9NO5S 

Molecular Weight : 267.26 

Iupac Chemical Name : NSC697923 

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SynonymsN/A 
Molecular FormulaC11H9NO5S 
Molecular Weight267.26 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.NSC697923 selectively inhibits PMA-induced NF-B activation, and also inhibits IB phosphorylation by both RANKL and LPS. NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-B activity in ABC-DLBCL cells. In addition, NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, and also induces apoptosis of primary DLBCL cells. [1] In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation. 

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