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NSC697923

Catalog No: 16122791
CAS Number: 343351-67-7
Purity: 98% 

NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.NSC697923 selectively inhibits PMA-induced NF-B activation, and also inhibits IB phosphorylation by both RANKL and LPS. NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-B activity in ABC-DLBCL cells. In addition, NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, and also induces apoptosis of primary DLBCL cells. [1] In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation. 

For research use only. We do not sell to patients.

Chemical Information

NameNSC697923
Iupac Chemical NameNSC697923 
SynonymsN/A 
Molecular FormulaC11H9NO5S 
Molecular Weight267.26 
InChiKey
InChi
CAS Number343351-67-7
Related CAS

Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122791 - NSC697923 | CAS 343351-67-7

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